What is depression classified as




















However, it can still be common for a pregnant woman to experience depression. Symptoms of depression during pregnancy include:. Treatment for depression during pregnancy may focus entirely on talk therapy and other natural treatments. Your healthcare provider may encourage you to try an alternative option until after the birth of your baby. The risks for depression can continue after the baby arrives.

Postpartum depression , which is also called major depressive disorder with peripartum onset, is a serious concern for new mothers. Recognizing the symptoms may help you spot a problem and seek help before it becomes overwhelming.

Research has established a link between alcohol use and depression. People who have depression are more likely to misuse alcohol. Out of the Drinking alcohol frequently can make symptoms of depression worse, and people who have depression are more likely to misuse alcohol or become dependent on it.

Read the full list of 15 ways you may be able to avoid depression. Depression can be temporary, or it can be a long-term challenge. However, treatment often makes symptoms more manageable. Managing symptoms of depression involves finding the right combination of medications and therapies. They can help you create a different treatment plan that may work better in helping you manage your condition. Depression hurts. And while we often pair this mental illness with emotional pain like sadness, crying, and feelings of hopelessness, research shows….

My task was finding a way of making them…. The author shares how she went from anxiety to a deep depression to actively considering suicide. Read this article to understand what it really feels…. In , While depression can affect a person psychologically, it also has the….

Watching a friend live with depression can be painful, but there are ways to help. Learn what to do, avoid, and how to recognize the signs of suicidal…. People who experience anhedonia have a decreased ability to feel pleasure. Learn causes, risk factors, and treatments for anhedonia. A SAD lamp can help alleviate symptoms of seasonal affective disorder. Learn more about SAD lamps, how to use them, features to look for, and products…. Bipolar disorder is a mental health condition that causes extreme fluctuations in thinking, mood, and behavior, known as depression and mania or….

Experts say mushrooms contain a number of nutrients, including potassium and B vitamins, that can boost physical as well as mental health. Health Conditions Discover Plan Connect. Mental Health. Medically reviewed by Vara Saripalli, Psy. Depression symptoms. Depression causes. Treatment for depression. Natural remedies and lifestyle tips.

Depression test. Types of depression. Depression and anxiety. Depression and obsessive-compulsive disorder OCD. Depression with psychosis. Depression in pregnancy. Depression and alcohol. Preventing depression. Outlook for depression. Hall-Flavin, M. There is a problem with information submitted for this request. Sign up for free, and stay up-to-date on research advancements, health tips and current health topics, like COVID, plus expert advice on managing your health.

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American Psychiatric Association. NIH Senior Health. Centers for Disease Control and Prevention. Then, the assumptions of the discriminant analyses were tested linearity, normality, multilinearity, equal variances, and multivariate normal distribution of the predictors. Box's M -tests were performed to test the assumption of the homogeneity of covariance matrices. It should be mentioned that discriminant analysis is robust when the homogeneity of variances assumption is not met, provided the data do not contain important outliers.

For our data, the Box's M -test was interpreted in conjunction with the inspection of the log determinants. Considering our sample size and the absence of outliers, we concluded that the small deviations from homogeneity groups did not violate the assumptions of the discriminant analysis.

For each case Non-depressed vs. Moderately Depressed and Severely Depressed vs. Moderately Depressed , the discriminant was created as a linear combination of the nine independent variables. The standardized canonical coefficients of the discriminant function analysis were used to identify the most reliable variable for discriminating between Severely Depressed and Moderately Depressed groups as well as between Non-depressed and Moderately Depressed groups.

Then, the canonical discriminant function coefficients were calculated to obtain the Discriminant Function DF. Non-depressed, and Moderately Depressed vs. Severely Depressed.

For each case, the correspondent chi-squared was calculated to verify if the DF did better than the chance level of separating the two groups. With the aid of the DF, the accuracy of the classification was measured for each case.

Most participants were female sex The prevalence of MDE in this clinical sample was In the whole sample, 46 depressive patients were found to be severely depressed. Severe depression was found to be more frequent in women In contrast, there was not an association between sex and moderate depression. The Non-depressed and the Moderately Depressed groups were matched considering the demographic variables of the Severely Depressed group Table 1.

There was no statistically significant differences according to race Caucasians and non-Caucasians among the three groups. The human development index in our sample ranged from 0. As expected, all the DSM-5 symptoms were found to be more frequent in Severely Depressed and Moderately Depressed groups as compared to the control Non-depressed group.

Table 2. The relative frequencies of the DSM-5 criteria for major depressive episode among the groups. Group means were found to be significantly different for all DSM-5 criteria. Depressed mood was the most reliable variable for discriminating between groups, followed by sleep difficulties and poor concentration. The smallest discriminant ability was found for suicidality. The pooled within-groups correlations Table 3 identified the large correlations with the full discriminant model: Depressed mood, sleep difficulties, poor concentration, and fatigue.

The canonical discriminate function reached an eigenvalue of 6. Therefore, the DF significantly separated the two groups. Table 3. Pooled within-groups correlations between discriminating variables and standardized canonical discriminant function: Non-depression vs.

Severe depression. The highest value was fatigue. The analysis of the standardized canonical coefficients indicated that suicidality was the most reliable variable for discriminating between the groups, followed by anhedonia. The smallest discriminant ability was found for fatigue.

The lowest was fatigue. The canonical discriminate function reached an eigenvalue of 0. Figure 2. Summary of the results. Loss of interest or pleasure discriminates severely depressed SD group from MD. The ellipses represent the non-somatic DSM-5 items and the rectangles the somatic DSM-5 items, according to the factor structure described by Elhai et al.

DM, depressed mood; LI, loss of interest or pleasure; SD, sleep difficulties insomnia or hypersomnia ; C, diminished ability to think or concentrate; FE, fatigue or loss of energy; FW, feelings of worthlessness or excessive guilt; SU, suicidality; AW, appetite or weight disturbance; PAR, psychomotor agitation or retardation. The two main diagnostic criteria for depression depressed mood and loss of interest or pleasure differ regarding their discrimination ability when the level of depression is considered: depressed mood is the most reliable DSM-5 symptom to discriminate moderate depression from non-depression whereas anhedonia emerges as an important criterion when depression becomes more severe.

Among the secondary DSM criteria, the somatic cluster shows high discriminant ability to separate non-depression from moderate depression. For the discrimination of severe from moderate depression, the most reliable DSM-5 symptom is suicidality, followed by anhedonia, feelings of worthlessness and depressed mood. In summary, the non-somatic DSM-5 criteria are found to distinguish moderate from severe depression reliably, while the somatic factors are useful for the discrimination between moderate and non-depression groups.

The present data support a two-factor model of depression proposed by Elhai et al. Among the secondary DSM-5 symptoms, the somatic factors are related to moderate depression, whereas the non-somatic or cognitive-affective factors are related to severe depression. The finding that the two main criteria for depression depressed mood and anhedonia exhibit distinct discrimination ability may reflect the possible differences between these two symptoms.

Depressive mood is often associated with the presence of stressors 30 , often loss situations death, economic reversal, separation, illness, etc. Thus, it is possible to speculate that depressed mood may be considered a compound factor indicating either a response to stressful situations somatic factor or a sadness feeling affective factor. Anhedonia may indicate either loss of interest motivational anhedonia or absence of an anticipatory pleasure from future activities or loss of pleasure in response to stimuli that were previously perceived as rewarding consummatory anhedonia Therefore, anhedonia is fully related to the affective factor while depressed mood might be related to both affective and somatic factors stressful situations.

This might explain why depressed mood is a good discriminator of moderate from non-depressed groups. However, another interpretation is that HAMD simply gives more importance to depressed mood items than to anhedonia 14 , 16 , In line with these findings, increased inter-lead QT interval differences on lead electrocardiography QT dispersion or reduced heart rate variability HRV has been reported in depressed patients 19 , 35 — Thus, both conditions may predispose individuals with depression to ventricular tachycardia, ventricular fibrillation, myocardial ischemia, and sudden cardiac death 44 — However, research on depression and HRV has been typically conducted in patients with cardiovascular disease 46 — Our findings are in agreement with the recent report by Benvenuti et al.

Here we demonstrated that moderately and severely depressed patients may express symptoms of low mood or distress through two distinct clusters of DSM-5 criteria. The present study report that moderate depression is associated with the somatic cluster is in agreement with the previous finding of highest autonomic dysfunction in moderate depression as compared to all other groups, including control and severely depressed patients The somatic symptoms may be related to autonomic disturbances in depressed patients without known cardiovascular disease 52 , Likewise, the Mental Stress-Induced Myocardial Ischemia has already been described in a patient with normal coronary arteries and generalized anxiety disorder In this case, anxiety might be considered a somatic component of depression 54 — Decreasing serotonin may cause a decrease in parasympathetic activity 58 , and emotional response capabilities are marked peripherally by vagal efference to the heart 40 , Specifically, high parasympathetic tone helps to maintain heart stability and protect against possible adverse cardiac events 32 , Conversely, increased sympathetic tone increases the risk of malignant arrhythmias and sudden cardiac death Thus, a high degree of HRV provides cardioprotective effect whereas the reduction in HRV is associated with higher cardiovascular risk in depressed patients 43 , 51 , Although medication-free depressed patients already exhibit reductions in HRV 52 , the use of specific antidepressants e.

This poses an additional risk for the depressed patients. The finding that the somatic cluster is related to moderate depression indicates a decrease in parasympathetic activity leading to higher cardiovascular risk. Therefore, the present data suggest that the cluster of DSM-5 symptoms exhibited by the patient may guide the choice of the adequate antidepressant drug treatment.

In addition, severe depression was found to be linked to increased suicidality, highlighting the importance of needing clear markers of severe depression for clinicians to identify the patients are at risk for committing suicide In our study, the presence of the anhedonia main criterium indicates severe depression, especially when accompanied by feelings of worthless or excessive guilt, and thoughts of death.

Although serotonin has been the most studied neurotransmitter in depression, norepinephrine is also of importance in depressive disorders. An association of specific features and symptoms of depression and a deficiency or dysfunction of certain neurotransmitters has been proposed 65 — 67 : a serotonin deficiency is related to problems such as anxiety, obsessions, and compulsions whereas dysfunctional dopaminergic activity is implicated in problems of motivation and pleasure 66 — Accordingly, norepinephrine deficiency is associated with increased suicide risk 50 , 65 , A limitation of this study is the use of a clinical sample.



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